Black Cumin Seed Oil for ALLERGIES

The following journal article abstracts detail Nigella sativa’s immunomodulatory, 

antiinflammatory, bronchodilator, spasmolytic (spasm relief and antispasmodic) 

and antioxidant properties.

Source: International Journal of Pharmacognosy. 1995; Vol 33 (1): 16-20

Title: Effect of Nigella sativa volatile oil on Jurkat T cells Leukemia Polypeptides

Authors: Nabil Hailat, Ziad Bataineh, Shawkat Lafi, Essam Raweily, Mahmoud Aqel, 

Mohammad AL-Kitab and Sam Hanash.

Nigella sativa is a spicy plant that has brocnhodilatory. . . antibacterial. . . and 

immunopotentiating activities.

Source: Journal of Pakistani Medical Association. March 2001; Vol 51 (3): 

115-120 Title: Bronchodilator, spasmolytic and calcium antagonist activities of 

Nigella sativa seeds: a traditional medicine

Authors: A. H. Gilani, N. Aziz, I. M. Khurram, K. S. Chaudhary, A. Iqbal,

These data indicate that the crude extract of Nigella sativa seeds exhibits spasmo-

lytic and bronchodilator activities. . . Its usefulness for diarrhoea and asthma in 

traditional medicine, appears thus to be based on a sound mechanistic background.

Source: Planta Medica. 1995; Vol 61: 33- 36

Title: Fixed Oil of Nigella sativa and derived thymoquinone inhibit eicosanoid 

generation in Leucocytes and membrane lipid peroxidation.

Authors: Peter J. Houghton, Rema Zarka , Beatriz de las Heras, J. R. S. Hoult, 

These pharmacological properties of the oil support the traditional use of Nigella 

sativa and its derived products as a treatment for rheumatism and related 

inflammatory diseases.

Black Cumin Seed Oil as an ANTIBIOTIC

The following journal article abstracts detail Nigella sativa’s antibacterial, 

antifungal, antioxidant and immunostimulant properties:

Source: Acta Microbiologica Pol. 2000; Vol 49: 63-74

Title: Antimicrobial effect of crude extracts of Nigella sativa on multiple 

antibiotics- resistant bacteria

Authors: N. M. Morsi,

Different crude extracts of Nigella sativa were tested for antimicrobial 

effectiveness against different bacterial isolates. These isolates comprised 16 

gram negative and 6 gram positive representatives. They showed multiple 

resistance against antibiotics, specially the gram negative ones. Crude extracts of 

Nigella sativa showed a promising effect against some of the test organisms. 

The most effective extracts were the crude alkaloid and water extracts. 

Gram negative isolates were affected more than gram positive ones.

Source: Journal of Ethnopharmacology. 1991; Vol 34: 275- 278

Title: Studies on the antimicrobial activity of Nigella sativa seed 

Authors: M. S. M. Hanafy and M. E. Hatem

Filter paper discs impregnated with the diethyl ether extract of Nigella sativa 

seeds (25-400mg extract/disc) caused concentration dependent inhibition of 

gram positive bacteria represented by Staphylococcus aureus. Gram-negative 

bacteria represented by Pseudomonas aeruginosa and Escherichia coli (but not 

Salmonella typhimurium) and a pathogenic yeast Candida albicans. The extract 

showed antibacterial synergism with streptomycin and gentamicin and showed 

additive antibacterial action with spectinomycin, erythromycin, tobramycin, 

doxycycline, chloramphenicol, nalidixic acid, ampicillin, lincomycin and 

sulphamethoxyzole-trimethoprim combination.

Source: Phytotherapy Research. 2000; Vol 14: 323-328

Title: Anti-oxidant activity of Nigella sativa essential oil.

Authors: M. Burtis and F. Bucar,

The results of the present study, which demonstrate the radical scavenging activity 

of Nigella sativa, indicate that the use of black cumin seeds for the treatment of 

various inflammatory diseases seems quite useful and reasonable.

Black Cumin Seed Oil for ARTHRITIS

The following journal article abstracts detail Nigella sativa’s antiinflammatory, 

antirheumatic, antioxidant and analgesic (pain relief) properties:

Source: Planta Medica. 1995; Vol 61: 33- 36

Title: Fixed Oil of Nigella sativa and derived thymoquinone inhibit eicosanoid 

generation in Leucocytes and membrane lipid peroxidation.

Authors: Peter J. Houghton, Rema Zarka , Beatriz de las Heras, J. R. S. Hoult,

These pharmacological properties of the oil support the traditional use of Nigella 

sativa and its derived products as a treatment for rheumatism and related 

inflammatory diseases.

Source: Phytotherapy Research. 2000; Vol 14: 323-328

Title: Anti-oxidant activity of Nigella sativa essential oil.

Authors: M. Burtis and F. Bucar,

The results of the present study, which demonstrate the radical scavenging activity 

of Nigella sativa, indicate that the use of black cumin seeds for the treatment of 

various inflammatory diseases seems quite useful and reasonable.

Source: Journal of Ethnopharmacology. 2001; Vol 76: 45-48

Title: The anti-inflammatory, analgesic and anti-pyretic activity of Nigella sativa.

Authors: M. S. Al-Ghamdi,

. . . the pharmacological activities of Nigella sativa support its use in folk medicine 

to reduce pain and inflammation but further studies are needed to elucidate the 

exact mechanism of action by which Nigella sativa inhibits inflammation and pain.

Source: Federation of European Biochemical Societies. 1999; Vol 442: 

89-94 Title: Plant extracts from stinging nettle (Urtica dioica), an antirheumatic 

remedy, inhibit the proinflammatory transcription factor NF-kB.

Authors: K. Riehemann, B. Behnke, K. Schulze-Osthoff

Our results suggest that part of the antiinflammatory effect of Urtica extract may 

be ascribed to its inhibitory effect on NF- kB activation.

Source: Journal of Rheumatology. 2002; Vol 29: 659-666

Title: Immunosuppressant effect of IDS 30, a stinging nettle extract, on Myeloid 

Dendritic cells in Vitro. Authors: J. Broer, B. Behnke

This may contribute to the therapeutic effect of IDS 30 on T cell mediated

inflammatory diseases like Rheumatoid Arthritis.

Black Cumin Seed Oil for DIABETES

The following journal article abstracts detail Nigella sativa and Urticaceae’s 

hypoglycaemic, antioxidant, antiinflammatory, antihypertensive and cardiovascular

properties.

Source: Planta Medica. 2002; Vol 68: 465-466

Title: The hypoglycaemic effect of Nigella sativa oil is mediated by extrapancreatic 

actions.

Authors: M. El-Darkhakhny, N. Mady, N. Lembert, H. P. T. Ammon,

The blood lowering effect of Nigella sativa oil was, however, not paralleled by a 

stimulation of insulin release in the presence of Nigella sativa oil, nigellone or 

thymoquinone. The data indicate that the hypoglycaemic effect of Nigella sativa 

may be mediated by extrapancreatic actions rather than by stimulated insulin 

release.

Source: International Journal of Pharmacognosy. 1993; Vol 31 (2): 96-100

Title: Hypoglycaemic effects of the volatile oil of Nigella sativa seeds.

Authors: A. Al-Hadar, M. Aqel and Z. Hasan,

. . . The administration of the volatile oil was not found to alter basal insulin levels 

in all animal groups,which might suggest a non-insulin-mediated mechanism of 

action for the demonstrated hypoglycaemic activity. The mode of action of the 

hypoglycaemic effects exhibited by the volatile oil extracted from N. sativa seeds 

remains to be elucidated.

Source: Phytotherapy Research. 2000; Vol 14: 323- 328

Title: Antioxidant activity of Nigella sativa essential oil.

Authors: M. Burtis and F. Bucar,

The results of the present study, which demonstrate the radical scavenging activity 

of Nigella sativa, indicate that the use of black cumin seeds for the treatment of 

various inflammatory diseases seems quite useful and reasonable.

Source: General Pharmacology. 1993; Vol 24 (5): 1123-1131

Authors: E. H .Kamal, El-Tahir, M. S. Mohammad, Ashour and Mohammad and

M. Al-Harbi,

. . . The direct mechanisms may be due to the presence of thymoquinone in the 

volatile oil. The volatile oil seemed to possess the potential of being a potent 

centrally acting antihypertensive agent. 

Source: Journal of Ethnopharmacology. 2002; Vol 81: 105-109

Authors: L. Testai, S. Chericoni, V. Calderone, G. Nencioni, P. Nieri, I. Morelli and 

E. Martinotti

It is concluded that Urtica dioica can produce hypotensive responses, through a

vasorelaxing effect mediated by the release of endothelial nitric oxide and the

opening of potassium channels, and through a negative inotropic action.

Black Cumin Seed Oil for the HEART

The following journal article abstracts detail Nigella sativa’s antiinflammatory, 

antioxidant, antithrombolytic, diuretic, hypotensive and antihypertensive 

properties:

Source: Phytotherapy Research. 2000; Vol 14: 323-328

Title: Anti-oxidant activity of Nigella sativa essential oil.

Authors: M. Burtis and F. Bucar,

The results of the present study, which demonstrate the radical scavenging activity 

of Nigella sativa, indicate that the use of black cumin seeds for the treatment of 

various inflammatory diseases seems quite useful and reasonable.

Source: Biological Pharmaceutical Bulletin. 2001 Mar; Vol 24 (3) 307-310

Title: Hematological studies on black cumin oil from the seeds of the Nigella sativa.

Authors: S. Enomoto, R. Asano, Y. Iwahori, T. Narui, Y. Okada, A. N. Singab, T. Okuyama,

The methanol soluble portion of black cumin oil, which is prepared by 

compression of seeds of Nigella sativa L., showed inhibitory effects on arachidonic 

acid (AA)-induced platelet aggregation and blood coagulation. . . Compounds 

possessing aromatic hydroxyl and acetoxyl group had more potent activity than 

aspirin, which is well known as a remedy for thrombosis.

Source: Journal of Ethnopharmacology. July 2002; Vol 81 (2): 161-164

Authors: M. El-Dakhakhny, N. J. Madi, N. Lembert, H. P. Ammon,

The effects are probably due to an oxidative action. The data may in part explain 

the effect of the oil, its derived thymoquinone and nigellone in ameliorating 

inflammatory diseases.

Source: Pharmacology Research. March 2000; Vol 41 (3): 283-289 

Authors: M. N. Nagi, M. A. Mansour, 

The results indicate that thymoquinone is a potent superoxide radical scavenger, 

scavenging power being as effective as superoxide dismutase against superoxide. 

The superoxide scavenging and anti-lipid peroxidation may explain, in part, the 

protective effect of thymoquinone against doxorubicin induced cardio toxicity.

Source: General Pharmacology. 1993; Vol 24 (5): 1123-1131

Authors: Kamal E. H, El-Tahir, Mohammad M. S, Ashour and Mohammad M. Al-Harbi,

The direct mechanisms may be due to the presence of thymoquinone in the 

volatile oil. The volatile oil seemed to possess the potential of being a potent 

centrally acting anti-hypertensive agent.

Black Cumin Seed Oil for IMMUNODEFIECIENCY

The following journal article abstracts detail Nigella sativa’s immunostimulant 

(CD4, CD8 and NK cells), bronchodilatory, antibacterial, antitumorous, 

antiinflammatory, antioxidant and antifungal medicinal properties.

Source: Immunopharmacology. 1995; Vol 30: 147-155

Title: Nigella sativa: effect on human lymphocytes and polymorphonuclear 

leukocyte phagocytic activity

Authors: Afrozul Haq, Mohammad Abdullatif, Peter I. Lobo, Khalid S. A. Khabar, 

Kirtikant V. Sheth, Sultan T. Al Sedairy, 

For the first time in 1987, the effect of Nigella sativa on the immune response was 

evaluated in human volunteers. . . These workers showed that black seed enhanced 

by 55% the ratio between helper T cells (CD4) and the suppressor T cells (CD8) 

and a 30% average enhancement of the natural killer (NK) cell activity.

Source: International Journal of Pharmacognosy. 1995; Vol 33 (1): 16-20

Title: Effect of Nigella sativa volatile oil on Jurkat T cells Leukemia Polypeptides

Authors: Nabil Hailat, Ziad Bataineh, Shawkat Lafi, Essam Raweily, Mahmoud Aqel, 

Mohammad AL-Kitab and Sam Hanash.

Nigella sativa is a spicy plant that has bronchodilatory. . . antibacterial. . . and 

immunopotentiating activities.

Source: Cancer Detection and Prevention. 2001; Vol 25 (4): 362- 368 

Title: Inhibitory effects of thymoquinone against 20-methylcholabthrene-induced 

fibrosarcoma tumorigenesis.

Authors: O. A. Badary, A. M. Gamal El-Din,

Our data indicate the potential of Thymoquinone (TQ) as a powerful 

chemopreventive agent against 20-methylcholanthrene-induced fibrocarcinoma 

tumors. The possible modes of action of TQ may be through its antioxidant 

activity and interference with the DNA synthesis coupled with enhancement of 

detoxification processes.

Source: International Journal of Immunopharmacology. Sep 2000; Vol 22 (9): 729-740

Title: Protective effect of black seed oil (BSO) from Nigella sativa 

against murine cytomegalovirus infection. Authors: M. L. Salem, M. S. Hossain,

These results show that BSO exhibited a striking antiviral effect against murine 

cytomegalovirus infection. . . 

Source: Journal of Ethnopharmacology. 1991; Vol 34: 275- 278

Title: Studies on the antimicrobial activity of Nigella sativa seed. Authors: M. S. M. 

Hanafy and M. E. Hatem, . . . the diethyl ether extract of Nigella sativa seeds (25-

400mg extract/disc) caused concentration dependent inhibition of Gram-positive 

bacteria represented by Staphylococcus aureus. Gram-negative bacteria 

represented by Pseudomonas aeruginosa and Escherichia coli (but not Salmonella 

typhimurium) and a pathogenic yeast Candida albicans.

Black Cumin Seed Oil for the RESPIRATORY SYSTEM

The following journal article abstracts detail Nigella sativa’s immunostimulant, 

bronchodilatory, antibacterial, antitumorous, antiinflammatory, antioxidant and 

antifungal medicinal properties.

Source: Immunopharmacology. 1995; Vol 30: 147-155

Title: Nigella sativa: effect on human lymphocytes and polymorphonuclear 

leukocyte phagocytic activity

Authors: Afrozul Haq et al. 

For the first time in 1987, the effect of Nigella sativa on the immune response 

was evaluated in human volunteers. . . These workers showed that black seed 

enhanced by 55% the ratio between helper T cells (CD4) and the suppressor 

T cells (CD8), and a 30% average enhancement of the natural killer (NK) cell 

activity.

Source: International Journal of Pharmacognosy. 1995; Vol 33 (1): 16-20

Title: Effect of Nigella sativa volatile oil on Jurkat T cells Leukemia Polypeptides

Authors: Nabil Hailat et al.

Nigella sativa is a spicy plant that has brocnhodilatory. . . antibacterial. . . and 

immunopotentiating activities.

Source: Cancer Detection and Prevention. 2001; Vol 25 (4): 362- 368 

Title: Inhibitory effects of thymoquinone against 20-methylcholabthrene-induced 

fibrosarcoma tumorigenesis. Authors: O. A. Badary, A. M. Gamal El-Din,

Our data indicate the potential of Thymoquinone (TQ) as a powerful 

chemopreventive agent against 20-methylcholanthrene-induced fibrocarcinoma 

tumors. The possible modes of action of TQ may be through its antioxidant 

activity and interference with the DNA synthesis coupled with enhancement 

of detoxification processes.

Source: Phytotherapy Research. 2000; Vol 14: 323-328

Title: Anti-oxidiant activity of Nigella sativa essential oil.Authors: M. Burtis and 

F. Bucar,

The results of the present study, which demonstrate the radical scavenging 

activity of Nigella sativa, indicate that the use of black cumin seeds for the 

treatment of various inflammatory diseases seems quite useful and reasonable.

Source: Journal of Ethnopharmacology. 1991; Vol 34: 275- 278

Title: Studies on the antimicrobial activity of Nigella sativa seed. 

Authors: M. S. M Hanafy and M. E. Hatem,

. . . the diethyl ether extract of Nigella sativa seeds (25-400mg extract/disc) 

caused concentration dependent inhibition of Gram-positive bacteria 

represented by Staphylococcus aureus. Gram-negative bacteria represented

by Pseudomonas aeruginosa and Escherichia coli (but not Salmonella 

typhimurium) and a pathogenic yeast Candida albicans.

Black Cumin Seed Oil for the SKIN

Dr Peter Schleicher, an immunologist from Munich, tested Nigella sativa seed oil 

on over 600 patients suffering from various autoimmune disorders (allergies) 

including asthma, hayfever, dust and pollen allergies.Dr Schleicher testifies to 

massive improvements in his patients conditions and has written a book on the 

subject (Black Cumin: The Magical Egyptian Herb for Allergies, Asthma, Skin 

Conditions and Immune Disorders).

The following journal article abstracts detail Nigella sativa’s antiinflammatory, 

antioxidant, antibacterial and antifungal properties.

Source: Phytotherapy Research. 2000; Vol 14: 323-328

Title: Anti-oxidant activity of Nigella sativa essential oil.

Authors: M. Burtis and F. Bucar,

The results of the present study, which demonstrate the radical scavenging 

activity of Nigella sativa, indicate that the use of black cumin seeds for the 

treatment of various inflammatory diseases seems quite useful and reasonable.

Source: Journal of Ethnopharmacology. 2001; Vol 76: 45-48

Title: The anti-inflammatory, analgesic and anti-pyretic activity of Nigella sativa.

Authors: M. S. Al-Ghamdi,

In conclusion, the pharmacological activities of Nigella sativa support its use in 

folk medicine to reduce pain and inflammation but further studies are needed 

to elucidate the exact mechanism of action by which Nigella sativa inhibits 

inflammation and pain.

Source: Journal of Ethnopharmacology. 1991; Vol 34: 275- 278

Title: Studies on the antimicrobial activity of Nigella sativa seed 

Authors: M. S. M. Hanafy and M. E. Hatem,

Filter paper discs impregnated with the diethyl ether extract of Nigella sativa 

seeds (25-400mg extract/disc) caused concentration dependent inhibition of 

Gram-positive bacteria represented by Staphylococcus aureus. Gram-negative 

bacteria represented by Pseudomonas aeruginosa and Escherichia coli (but not 

Salmonella typhimurium) and a pathogenic yeast Candida albicans.

Stinging Nettle Seed Oil for Benign Prostatic Hyperplasia and Prostitis

The following journal article abstracts detail Stinging Nettle’s benefits in treating benign

prostatic hyperplasia and antioxidant properties.

Source: The Annals od Pharmacopherapy. 2002; Vol 36: 1443-1451

Title: Herbs for Benign Prostatic Hyperplasia.

Authors: L. Dvorkin and K. Y. Song,Mohammad AL-Kitab and Sam Hanash.

Based on the information available today, these botanical therapies can be used for treatment of a 

number of objective and subjective symptoms in patients with BPH, stages I and II.

Source: Clinical Therapeutics (1993) Vol 15: No 6, 1011- 1020

Title: Combined extracts of Urtica dioica and Pygeum africanum inthe treatment of benign prostatic 

hyperplasia: Double Blindcomparison of two doses

Authors: T. Krzeski, M. Kazon, A. Borkowski, A. Witeska and J. Kuczerna

. . . the Urtica/ pygeum extract ase as safe and effective as the recommendedfull doses. 

Source: Planta Medica (1994), Vol 60:

Title: Effects of Stinging Nettle root extracts and their steroidal componentson the Na+, K+ -ATPase 

of the benign prostatic hyperplasia

AutHors: T. Hirano, M. Homma and K. OkaThese results suggest 

that some hydrophobic constituents such as steroids inthe stinging nettle roots inhibited the 

membrane Na+, K+ATPase activity ofthe prostate, which may subsequently suppress prostate-cell 

metabolism and growth.

Stinging Nettle Seed Oil for Arthritis, Rheumatism and Gout

The following journal article abstracts detail Stinging Nettle’s antirheumatic,

antiarthritic, antiinflammatory, and antioxidant properties.


Source: Histol Histopathol (2002), 17: 477- 485

Title: Effects of the

antirheumatic remedy Hox Alpha- a new stinging nettle leaf extract- on matrix

metalloproteinases in human chondrocytes in vitro Authors: G. Schultze- Tanzil, P. de Souza, 

B. Behnke, S. Klingelhoefer, A. Scheld and M. Shakibaei

The potential of Hox Alpha and 13- HOTrE to supress the expression of matrix

metalloproteinases may explain the clinical efficacy of stinging nettle leaf

extracts in treatment of rheumatoid arthritis. These results suggest that the

monosubstance 13-HOTrE is one of the more active antiinflammatory substances

in Hox alpha and that Hox alpha may be a promising remedy for therapy of

inflammatory joint diseases

Source: Phytotherapy Research 2002, Vol 16: 467- 473Title: In vitro Antioxidant Activity of Non- 

cultivated Vegetables of Ethnic

Albanians in Southern ItalyAuthors: A. Pieroni, V. Janiak, C. M. Durr, S. Ludeke, E. Trachsel and

M. heinrichThese finding suggest that weedy vegetables may be useful antioxidants of

interest in the prevention of ageing related diseases, CNS disorders and as

potential sources of phytomedicines against hyperuricaemia and gout.

Source: Planta Medica 2001, Vol 67: 489- 500

Title: Extracts from Fruits of Saw Palmetto and roots of Stinging Nettle:

Viable Alternatives in the medical treatment of benign prostatic hyperplasic

and associated lower urinary tracts symptoms.

Author: Egon Kock.

These investigations have not only broadened the scientific basis for the

rational use of phytotherapeutics but have also provided evidence for their

therapeutic efficacy and favourable safety profile.

Source: The Journal of Rheumatology 2002, Vol 29: 659- 66

Title: Immunosupressant Effect of IDS 30, a Stinging Nettle Leaf Extract, on

Myeloid Dendritic Cells in Vitro

Author: J. Broer and B. Behnke.

Our in vitro results showed the supressive effect of IDS 30 on the maturation

of human myeloid dendritic cells, leading to reduced induction of primary

T cell responses. This may contribute to the therapeutic effect of IDS 30 on

T cell mediated inflammatory diseases like Rheumatoid Arthritis

Source: Complementary Therapies in Medicine

Title: Nettle sting of Urtica dioica for joint pain- an exploratory study of

this complemetary therapy

Authors: C. Randall, K. Meethan, H. Randall, F. Dobbs

This exploratory study suggests nettle sting is a useful, safe and cheap

therapy which needs further study. A randomized controlled trial is planned in

collaboration with a rheumatology specialist

Source: FEBS Letters 1999, Vol 442: 89- 94

Title: Plant extract from Stinging Nettle (Urtica dioica), an antirheumatic

remedy, inhibit the proinflammatory transcription factor NF-KB

Authors: K. Riehemann, B. Behnke, K. Schulze- Osthoff

Our results suggest that part of the antiinflammatory effect of Urtica extract

may be ascribed to its inhibitory effect on NF- KB activaton

Stinging Nettle Seed Oil for the Immune System

The following journal article abstracts document stinging nettles

Source: Phytotherapy Research (2003), Vol17: 34- 37

Title: In vitro Immunomodulatory Activity of Flavanoid Glycosides from Urtica dioica (Latin)

Authors: P. Akbay, A. A. Basaran, U. Undeger and N. Basaran

The results of both essays confirmed the immunomodulatory activity of the flavanoid fraction and 

the isolated flavanoid glycosides on neutrophils suggesting that they could possibly be useful for 

treating patients suffering from neutrophil function deficiency and chromite granulomatous diseases.
Source: Antiviral Research (1992), Vol 18: 191- 207

Title: The mannose- specific plant lectins from Cymbidiu, hybrid and Epipactis helleborine and the

(N- acetylglucosamine)n- specific plant lectin from Urtica dioica are potent and selective inhibitors of 

human immunodeficiency virus and cytomegalovirus replication in vitro

Authors: J. Balzarini, J. Neyts, D. Schols, MHosoya, E. V. Damme, W. Peumans and E. D. Clercq

Also, the (GlcNAc)n- specific lectin from Urtica dioica was inhibitory to HIV- 1, HIV- 2, CMV, RSV- 

and influenza A virus- induced cytopathicity at an EC50 ranging from 0.3 to 9 ug/ml.